Synergistic anticancer activity of disulfiram/copper against mouse lymphoma cells
نویسندگان
چکیده
Disulfiram (DSF) is a marketed drug to treat patients with alcohol dependence by inhibiting aldehyde dehydrogenase. Over the last few decades, DSF has been shown have anticancer effects through different mechanisms. Moreover, this effect can be elevated when used copper (Cu). Subsequent studies conducted on various cancers, but lymphoma. This study investigated of lymphoma and how changed treated Cu. synergistically decreased metabolic activity EL4 cells combined At 1 µM alone, 49% compared control, whereas it 87% + CuCl2 treatment. Rhodamine 123 2',7'–dichlorofluorescein diacetate staining showed that induced reduction mitochondrial membrane potential promoted production reactive oxygen species. In particular, treatment Cu cell death based multiple assays, including annexin V-fluorescein isothiocyanate/propidium iodide staining. Overall, exhibits synergistic provides some valuable information broaden use in clinics basic research.
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ژورنال
عنوان ژورنال: Korean journal of veterinary research
سال: 2022
ISSN: ['2466-1384', '2466-1392']
DOI: https://doi.org/10.14405/kjvr.20210040